In Japan, the prevalence of non-communicable diseases (NCDs) such as cancer, diabetes, dyslipidemia, and hypertension is increasing. Furthermore, many studies have reported that nutritional status in utero to infancy influences the risk of development of NCDs, which is known as Developmental Origins of Health and Disease (DOHaD). Many patients with NCDs require long-term medication, and often need to modify their diet and physical activity in their daily lives. 　The center is conducting research to elucidate environmental factors, including the genetic background of patients over the life course, with regard to nutritional intake that influences the prevention of the onset and severity of NCDs. Based on these results, we aim to establish individualized nutritional management therapies for each patient.

・Laboratory of Nutrition Therapy
In order to reduce the risk of disease for the next generation, we are engaged in research that contributes to the development of individualized measures against malnutrition, through a longitudinal survey on nutrition and dietary habits among pregnant women in Settsu City, as well as conducting research on the development of a questionnaire for precise estimation of the dietary intake of infants, in cooperation with the Nutrition Epidemiology and Policy Research Center and the Physical Activity Research Center.

・Laboratory of Nutrition Metabolism
　We conduct research on energy metabolism and appropriate intake of major nutrients such as protein, fat, and carbohydrates, with the aim of contributing to the establishment of dietary intake standards for energy and major nutrients. We also conduct research on the pathogenesis of obesity and lifestyle-related diseases caused by excessive or insufficient intake of these nutrients, as well as on methods to prevent these diseases.

・Laboratory of Behavioral Physiology
　We aim to clarify how daily behaviors and lifestyle habits, such as diet, nutrition, and physical activity, are involved in the development of health and disease, to elucidate the interactions between these lifestyle factors and genetic factors and intestinal bacteria, and to propose behaviors and lifestyle habits for health promotion tailored to individual characteristics. We also aim to identify risk factors for people at high risk of low nutrition and frailty, and to build evidence that will contribute to the prevention of serious illness.